Job ID 12423 Location Case Main Campus Full/Part Time Full-Time Regular/Temporary Regular Job Description POSITION OBJECTIVE Working with a high degree of independence and under general supervision, coordinate major activities in medical and related technical areas related to the use spatial-omic systems and other advanced microscopy instruments (e.g., light-sheet microscopy, confocal microscopy, etc.). The position manage the preparation of slides for our spatial multi-omic imaging systems, provide in-depth training, assist with tissue preparation for light-sheet microscopy, aid with user troubleshooting, maintain instruments, advise on image analysis, and more. ESSENTIAL FUNCTIONS Provide input and recommendations to the operations manager and director regarding significant developments in service-oriented research projects related to the use spatial-omic systems and other advanced microscopy instruments. (10%) Coordinate major activities of laboratory/research in accordance with general plans to assist users work with the histology cores to get formalin-fixed paraffin-embedded (FFPE) or fresh frozen (FE) tissue slides. (10%) Perform the most complex quantitative analytical experiments to supply scientific information as a part of a larger project. Manage the preparation of slides for the CosMx imaging system from Nanostring, following the precise two-day protocol to prepare slides. Prepare slides for the Xenium imaging system from 10X Genomics, following the two-day protocol to prepare slides. (40%) Assist and train collaborators to prepare their tissues for light-sheet microscopy (e.g., optical clearing, whole-mount staining, etc.). Hold training sessions or tours for educational purposes. May train new staff; direct the work of students. (10%) Collect and analyze data and advise on image analysis. Analyze visualization data utilizing programs provided be respective customer companies which may involve basic Python scripting. (10%) May assist in developing improved techniques, projection methods or procedures including optical clearing techniques, data visualization techniques, and quality control procedures. May assist in improving processes and techniques provided by respective companies. Assist with user troubleshooting. (10%) NONESSENTIAL FUNCTIONS Perform other duties as assigned (5%) Oversee inventory and assist with maintenance or training on microscopy instruments (5%) CONTACTS Department: Frequent contact with director, operations manager, and other staff. University: Frequent contact with principal investigators and other research personnel and faculty and staff within the School of Medicine to collaborate on complex research. Regular contact with administrative offices and research administration within the school and the university to resolve issues. External: Not frequent-may have contact with external users of the instruments. Students: Daily contact with student employees to maintain workflow, make adjustment to work, and/or establish procedures. SUPERVISORY RESPONSIBILITY May supervise and train staff and users of our equipment. QUALIFICATIONS Experience: 5 to 8 years of related experience required. Prior experience with slide preparation is preferred. Advanced biology and wet lab experience is required. Education: Bachelor's degree in biology, chemistry, or related scientific field science. REQUIRED SKILLS Common wet lab techniques (e.g., pipetting, preparing mixtures, etc.). Advanced biology and genetic knowledge. Must be extremely careful and precise. Ability to understand scientific literature, experimental procedures and their limitations, and current needs of the research community. Ability to problem solve effectively and demonstrate good judgement and logical decision making and ability to implement altern