Job ID 12425 Location Case Main Campus Full/Part Time Full-Time Regular/Temporary Regular Job Description POSITION OBJECTIVE Working under moderate supervision, perform research work in close collaboration and discussion with the Principle Investigator. The lab will work closely with other principle investigators in Pathology and School of Medicine including collaborations with a multidisciplinary team of biologists, chemists, physicists and clinicians at the university, and neighboring institutes. This position will work with animals. ESSENTIAL FUNCTIONS Perform research work in medical, biological and related technical areas involving use of lab skills related to Acute Myeloid Leukemia with the goal to discover novel molecular mechanisms that could be targeted to develop new therapeutic approaches. Regulation of cellular signaling by hexosamine biosynthetic pathway, O-GlcNAcylation and NF-kB transcription pathways are key areas of attention. (60%) Conduct analysis of samples utilizing techniques ranging from basic cell and molecular biology, immunology, biochemistry to cell culture, animal studies, and patient samples. (20%) Record results for a particular experiment or closely related series of experiments, present results in one-on-one meeting with the principal investigator and lab meetings. Maintain detailed records of experiments with all necessary documents to reproduce the study in electronic and/or hard copy lab notebook. (10%) NONESSENTIAL FUNCTIONS Order laboratory supplies. Organize lab inventory and Maintain equipment utilized in experiments. (5%) Perform other duties as assigned. (5%) CONTACTS Department: Almost daily contact with supervisor, either in person or through electronic media to discuss research and maintain workflow. Students: Contact with student and postdoc employees to exchange information. University: Occasional contact with members of other departments, animal facility, clinical staff and administrators to share to support research activities. External: Limited contact with vendors to exchange information necessary for purchase and protocol details. Students: No contact with students. SUPERVISORY RESPONSIBILITY This position has no direct supervision of staff employees. QUALIFICATIONS Education/Experience: Bachelor's degree in science and 0 to 1 year of experience or Associate's degree in an approved biotechnology program and 0 to 2 years of experience required. REQUIRED SKILLS Experience with mouse models and flow cytometry is required. Has knowledge of commonly-used concepts, practices, and procedures within the field of oncology, immunology, biochemistry. Relies on instructions and pre-established guidelines to perform the functions of the job and shows ability to come up with novel ideas and directions to strengthen the project. Ability to operate all the common laboratory equipment. Ability to meet consistent attendance. Ability to interact with colleagues, supervisors and customers face to face. Effective oral and written communication skills. Good organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy and follow-through on assigned tasks. Ability to work with sensitive information and maintain confidentiality. Good problem-solving skills; must demonstrate good analytical skills, sound judgment and good decision-making. Familiarity with policies and procedures of lab and adhere to chemical and biological safety and manage them. Perform/supervise rodent husbandry including breeding, genotyping and maintain an accurate animal database. Compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other appli